Following the adventures of two alchemist brothers who seek to repair their bodies after using Alchemy breaking the laws of nature by trying to bring their mother back to life. Betrayal and double-crossing are the order of the day. Greed, Pride and Envy prove to be formidable enemies, but one homunculus seems to be having pangs of conscience. Ominous news spreads quickly about a mysterious portal.

Will this gateway help the Elric brothers regain their natural bodies? And will the gigantic underground transmutation circle be completed, leading to a major regime change?